Abstract
for the RCE
Bacillus
anthracis Host
Interactions
Discovery
of Subunit Vaccine Candidates against
Glanders
Alphavirus
Vaccines for Biodefense
Novel
Genetic Tools for Viral Biodefense
Development
and Evaluation of Human
Brucellosis
Vaccines
Rapid
Diagnostic Tools for Q Fever
New
Diagnostic Methods for Accute Rickettsial
Infections
Risks
and Interventions for Pandemic Influenza
Development
of Novel Pseudoinfectious Flavivirus Vaccines
Development
of Diagnostic Reagents for the detection
of
Francisella and
Francisella
Infection
Toward
Control of Rift Valley Fever Virus
Replication
Novel
Vaccine Technology for Biodefense
Nucleocapsid-specific
Small Molecule Inhibitors
of
the Bunyaviridae
New
Technologies for Creating Affinity Reagents
New Opportunities Projects
Identification
and Characterization of Novel
Flavivirus
Antivirals
Biosafety
Containment Training Program
Passive
Immunotherapeutics for
Select
Agents
Preclinical
Testing of YF17D/LAS, a Bivalent
Vaccine
for Lassa and
Yellow
Fever
|
Biosafety
Containment Training Program
Collaborating
Institution: University of Texas Medical Branch (UTMB), Galveston,
TX
Principal
Investigator: Anne-Sophie Brocard, PhD
Expected
Product: Establishment of a standardized training course for
biosafety containment work.
Description: The UTMB Environmental Health and Safety (EHS) Biocontainment
Training Program has been developed and was successfully implemented
last year. As part of the Western Regional Center for Biodefense
and Emerging Infectious Diseases Research (WRCE), we would like
to be able to respond to the needs of WRCE members to train personnel
and alleviate initial training time from researchers. This program
is the first of its kind, as it is customized to the need of
the bench scientist, principal investigator, and facility in
which the research will be conducted. The program has resulted
in groundbreaking efforts towards standardizing safety practices
in biocontainment facilities allowing a smooth transition of
personnel within facilities as well as for collaborative interactions.
As
funding increases for infectious disease research with the
emphasis on emerging infectious diseases, training in biocontainment
becomes more critical due to the increase in potential laboratory-acquired
infections due to a lack of proper training. The program is
offered
to BSL2, BSL3, and BSL4 users, with a strong emphasis on BSL3
training, since BSL3 users are at greater risk for laboratory-acquired
exposures.
Emphasis will be directed towards the protection of the laboratorian
as well as protection of research materials from contamination.
The training program offered is a hands-on course with needed
theoretical information to support the practical training.
The program is designed
to address the specific needs of each scientist based on his
or her research utilizing a one-on-one training focus. This
model allows attention to specific details in manipulation techniques. User
confidence is enhanced when training is in a controlled nonhazardous
environment, allowing errors to occur without consequences
to the trainee and environment. For example, the time and resources
traditionally
dedicated to the initial BSL4 suit training will be accomplished
as part of the training program. Following containment training,
the trainees will then finish their in-lab mentoring with experienced
users focusing on their area of research. In-lab mentorship
will be reduced, the trainees will have mastered standardized
laboratory
practices, and the BSL4 trainee will have had suit training
prior to entering the laboratory.
The
program is designed specifically to accommodate the needs of
scientists, principal investigators, and institutions. The
core has the capability to offer a refresher course or to customize
training related to biosafety/biocontainment if there is
a request
by WRCE scientists or support staff.
The
training program will allow all scientists a standardized training
course in biosafety containment work from BSL2 to
BSL4 levels, thus alleviating resources of PI and allowing
research to continue. |