Nonhuman Primate Core

Computational Biology Core

Small Animal Core

BSL4 Core

Pathogenesis Expression Core

Law, Policy and Ethics

Trans-Center Cores

National Small Molecule Screening Laboratory

RCE Communications

Nonhuman Primate Aerobiology Core

Passive immunotherapeutics for                             Select Agents

The National Screening Laboratory for the RCE

Host Institution (RCE): Harvard Medical School, Boston, MA (New England RCE)

Director: Stephen Lory, Ph.D. – Harvard Medical School, Boston, MA

Associate Directors:
a) Jon Clardy, Ph.D. – Harvard Medical School, Boston, MA
b) Greg Cuny, Ph.D. – Harvard Medical School, Boston, MA

Description: The National Screening Laboratory for the Regional Centers of Excellence in Biodefense and Emerging Infectious Disease (NSRB) provides resources, instruments, and expertise for high-throughput screening of small molecule libraries for investigators across the country conducting research on NIAID Priority Pathogens. The Laboratory includes a fully equipped screening facility, staffed by personnel with expertise in microbiology and in the development and implementation of high-throughput screening, as well as a medicinal chemistry group. The Laboratory is an expansion of the existing NERCE screening operation at Harvard Medical School (HMS) and interacts closely with other programs at HMS that share similar missions: the Institute of Chemistry and Cell Biology (ICCB) and the Laboratory for Drug Discovery in Neurodegeneration (LDDN). The RCE Trans-center Small Molecule Screening Laboratory shares access to small molecule libraries, expertise in organic chemistry, and use of computational resources with ICCB and LDDN. The Laboratory supports multiple screening platforms and will establish a medicinal chemistry capability to advance the most promising hits identified by screening towards pharmaceutical development.
Investigators are urged to visit the NSRB web site at: http://nsrb.med.harvard.edu/
An application for screening, the screening process, and other useful information for accessing this core facility can be found on the web site.