Recombinant
Genetics Development
for Junin Viruses
Improving
Small Animal Models of Chikungunya Fever for Development of
New Live-attenuated Vaccines
Nipah
Virus-like Particles for Vaccine Development
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Description: The purpose of the Western Regional Center for Biodefense and Emerging
Infectious Disease Research (WRCE) Developmental Research program
is to provide overall guidance required to solicit, evaluate, select,
and manage pilot research projects that are critical to the development
and sustainability of a productive basic and applied biodefense
research program. The program will function as an integral component
of the WRCE’s mission by expanding the scope of research,
increasing the pool of biodefense researchers and the number of
institutions involved in the WRCE, opening up new lines of research,
and developing new technologies needed to contribute to the development
of mission-relevant countermeasures. The Developmental Research
plan takes advantage of the region’s wealth of relevant scientific
expertise by identifying and promoting new research ideas, and
employing and developing novel technologies. The research projects
will be conducted by established biodefense and emerging infectious
disease investigators, and by researchers new to the field, who
are willing to apply their expertise to conduct a novel aspect
of product-oriented research. A systematic and rigorous administrative
and scientific management plan, similar to the plan used during
the first WRCE grant cycle, will be employed to allow for the selection
of the most relevant and scientifically sound research projects,
and for effective monitoring and evaluation of progress. The WRCE
Director will have overall responsibility for the Developmental
Research program and will designate the WRCE Associate Director
to manage the plan. The Associate Director will be supported by
the WRCE Program Administrator, other key WRCE Administrative Core
personnel, and the WRCE Research Project Theme Leaders. In addition,
the WRCE Associate Director for Product Development and the WRCE
Steering Committee will be called upon as needed when decisions
are made regarding continued support for productive projects, the
redirection of projects, or the discontinuation of unproductive
projects. Also, the selection of new projects will rely upon the
scientific expertise of the Steering Committee, the WRCE Director,
and the NIAID program officers. This expertise, working in concert,
contributes to the establishment and sustainability of productive
Developmental Research projects within the WRCE.
The WRCE Developmental
Research program takes advantage of emergent technology and new
research opportunities to support NIAID’s
efforts to support multifaceted research to provide scientific
information and translational research capacity that will facilitate
the next generation of therapeutics, diagnostics, and vaccines
against the NIAID Category A-C Priority Pathogens and Emerging
and Re-emerging Disease Agents.
Three Developmental Projects have been selected to date, and all
happen to be in the Vaccine Development for Arboviral and Emerging
Viral Diseases theme (Theme 2). They include:
1. DP 001, “Recombinant Genetics Development for Junin Viruses”,
Slobodan Paessler, University of Texas Medical Branch, Galveston,
TX.
2. DP 002, “Improving Small Animal Models of Chikungunya
Fever for Development of New Live-attenuated Vaccines”, Kate
Ryman, Louisiana State University Health Sciences Center, Shreveport,
LA.
3. DP 003, “Nipah Virus-like Particles for Vaccine Development”,
Pramila Walpita, University of Texas Medical Branch, Galveston,
TX.
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